MDM2 הוא רגולטור שלילי חשוב של החלבון p53 שמונע גידולים. הוא השם גם של הגן וגם של החלבון שהגן מקדד.

MDM2
מבנים זמינים
בנק מידע החלבוניםחיפוש אורתולוגים: PDBe RCSB
רשימת מבנים

1RV1, 1T4E, 1T4F, 1YCR, 1Z1M, 2AXI, 2C6A, 2C6B, 2FOP, 2GV2, 2HDP, 2LZG, 2M86, 2MPS, 2RUH, 2VJE, 2VJF, 3EQS, 3G03, 3IUX, 3IWY, 3JZK, 3JZR, 3JZS, 3LBK, 3LBL, 3LNJ, 3LNZ, 3MQS, 3TJ2, 3TPX, 3TU1, 3V3B, 3VBG, 3VZV, 3W69, 4DIJ, 4ERE, 4ERF, 4HBM, 4HFZ, 4HG7, 4JV7, 4JV9, 4JVE, 4JVR, 4JWR, 4MDN, 4MDQ, 4OAS, 4OBA, 4OCC, 4ODE, 4ODF, 4OGN, 4OGT, 4OGV, 4OQ3, 4QO4, 4QOC, 4UMN, 4WT2, 4XXB, 4ZYC, 4ZYF, 4ZYI, 4UE1, 4UD7, 5AFG, 5HMI, 5HMK, 5HMH, 5C5A

מזהים
שמות נוספיםMDM2, ACTFS, HDMX, hdm2, MDM2 proto-oncogene, LSKB
מזהים חיצונייםOMIM: 164785 MGI: 96952 HomoloGene: 1793 GeneCards: MDM2
מיקום הגן (באדם)
כרומוזום 12
כרומוזוםכרומוזום 12[1]
כרומוזום 12
מיקום גנומי עבור MDM2
מיקום גנומי עבור MDM2
עמדה12q15התחלה68,808,177 bp[1]
סוף68,845,544 bp[1]
מיקום הגן (בעכבר)
כרומוזום 10 (בעכבר)
כרומוזוםכרומוזום 10 (בעכבר)[2]
כרומוזום 10 (בעכבר)
מיקום גנומי עבור MDM2
מיקום גנומי עבור MDM2
עמדה10 D2|10 66.32 cMהתחלה117,524,780 bp[2]
סוף117,546,663 bp[2]
תבנית ביטוי RNA




נתוני התבטאות נוספים
אונטולוגיית גנים (GO)
תפקיד מולקולרי scaffold protein binding
GO:0001948, GO:0016582 קשירת חלבונים
enzyme binding
קשירת יוני מתכת
קשירת חלבון דומה
UB
p53 binding
SUMO transferase activity
GO:0050372 ubiquitin-protein transferase activity
פעילות טרנספראז
ligase activity
5S rRNA binding
zinc ion binding
ribonucleoprotein complex binding
protein N-terminus binding
GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity
NEDD8 ligase activity
disordered domain specific binding
protein domain specific binding
receptor serine/threonine kinase binding
peroxisome proliferator activated receptor binding
ubiquitin binding
מיקום בתא ציטוזול
endocytic vesicle membrane
קרום התא
סינפסה
nuclear body
ציטופלזמה
גרעין התא
נוקלאופלזמה
גרעינון
GO:0009327 מבנה מקרומולקולרי
תהליכים ביולוגיים negative regulation of signal transduction by p53 class mediator
endocardial cushion morphogenesis
cellular response to UV-C
atrial septum development
regulation of heart rate
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:1901313 בקרה חיובית של ביטוי גנים
blood vessel development
בקרה חיובית של שגשוג תאים
negative regulation of DNA damage response, signal transduction by p53 class mediator
response to ether
blood vessel remodeling
cellular response to hypoxia
heart valve development
cellular response to estrogen stimulus
בקרה שלילית של תהליך אפופטוזה
cellular response to organic substance
cellular response to hydrogen peroxide
response to cocaine
cardiac septum morphogenesis
GO:1901227 negative regulation of transcription by RNA polymerase II
GO:0018054 peptidyl-lysine modification
positive regulation of cell cycle
ventricular septum development
positive regulation of protein export from nucleus
response to steroid hormone
cellular response to growth factor stimulus
GO:1903362 regulation of protein catabolic process
GO:1904577 cellular response to antibiotic
negative regulation of gene expression
positive regulation of mitotic cell cycle
heart development
cellular response to alkaloid
cellular response to vitamin B1
response to magnesium ion
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to peptide hormone stimulus
GO:1904579 cellular response to organic cyclic compound
GO:0022415 viral process
response to iron ion
בקרת גנים
GO:1904576 response to antibiotic
traversing start control point of mitotic cell cycle
protein ubiquitination
negative regulation of protein processing
establishment of protein localization
response to toxic substance
response to morphine
atrioventricular valve morphogenesis
protein localization to nucleus
regulation of signal transduction by p53 class mediator
positive regulation of vascular associated smooth muscle cell proliferation
response to water-immersion restraint stress
negative regulation of neuron projection development
positive regulation of vascular associated smooth muscle cell migration
protein deubiquitination
protein sumoylation
transcription factor catabolic process
protein autoubiquitination
response to formaldehyde
protein destabilization
GO:0045996 negative regulation of transcription, DNA-templated
proteolysis involved in cellular protein catabolic process
cellular response to gamma radiation
cellular response to actinomycin D
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
amyloid fibril formation
GO:0034622 protein-containing complex assembly
ubiquitin-dependent protein catabolic process
מקורות: Amigo / QuickGO
אורתולוגים
מיניםאדםעכבר
Entrez
Ensembl
UniProt
RefSeq (mRNA)
NM_001145336
NM_001145337
NM_001145339
NM_001145340
NM_001278462

NM_002392
NM_006878
NM_006879
NM_006880
NM_006881
NM_006882
NM_032739
NM_001367990

NM_001288586
NM_010786

RefSeq (חלבון)
NP_001138809
NP_001138811
NP_001138812
NP_001265391
NP_002383

NP_001354919

NP_001275515
NP_034916

מיקום (UCSC)Chr 12: 68.81 – 68.85 MbChr 10: 117.52 – 117.55 Mb
חיפוש PubMed[3][4]
ויקינתונים
צפייה/עריכה נתוני אדםצפייה/עריכה נתוני עכבר

גילוי עריכה

האונקוגן שמקדד את החלבון MDM2 שובט לראשונה, ביחד עם הגנים MDM1 ו-MDM3, משורת התאים העכבריים 3T3-DM. ביטוי יתר שלו, יחד עם Ras האונקוגני מניע התמרה של פיברובלסטים עכבריים, וביטוי של MDM2 גורם ליצירת גידולים בעכברים ערומים. לחלבון זה קיים הומולוג אנושי שלפעמים נקרא HDM2. אישוש לכך של-MDM2 יש חלק בהתפתחות גידולים, חוקרים מצאו רמות מוגברות של החלבון בסוגי סרטן מסוימים. MDM4, שלפעמים נקרא MDMX, הוא באותה משפחה של MDM2, וגם לו יש תפקיד כרגולטור שלילי של p53.

אינטראקציות עריכה

המחקר הראה ש- MDM2 פועל ביחד עם HDAC1,[5] RPL26,[6] FKBP3,[7] CCNG1,[8] HTATIP,[9] GNL3,[10] Death associated protein 6,[11] PSME3,[12] Insulin-like growth factor 1 receptor,[13] RRM2B,[14] FOXO4,[15] Ribosomal protein L5,[10][16][17] ABL,[18] RYBP,[19] HIF1A,[20][21] PCAF,[22] TATA binding protein,[23][24] P73,[25][26] CTBP2,[27] NUMB,[28][29] P53,[30][31] P16,[11][16][32][33][34] PSMD10,[35] EP300,[36] CTBP1,[27] MDM4,[37][38][39][40] RPL11,[10][16] Promyelocytic leukemia protein,[41][42][43][44] Dihydrofolate reductase,[45] Arrestin beta 2,[46][47][48] Arrestin beta 1[47][48] ו- Ubiquitin C.[11][49][50]

 
מספר דרכים באפופטוזה של תאים

ראו גם עריכה

לקריאה נוספת עריכה

הערות שוליים עריכה

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