חוסמי תעלות סידן – הבדלי גרסאות
תוכן שנמחק תוכן שנוסף
מאין תקציר עריכה |
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שורה 25:
== מנגנון הפעולה ==
Voltage-sensitive Ca2+ channels (L-type or slow channels) mediate the entry of extracellular Ca2+ into smooth muscle and cardiac myocytes and sinoatrial (SA) and atrioventricular (AV) nodal cells in response to electrical depolarization. In both smooth muscle and cardiac myocytes, Ca2+ is a trigger for contraction, albeit by different mechanisms. Ca2+ channel antagonists, also called Ca2+ entry blockers, inhibit Ca2+ channel function. In vascular smooth muscle, this leads to relaxation, especially in arterial beds. These drugs also may produce negative inotropic and chronotropic effects in the heart.
==הערות שוליים==
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