פתיחת התפריט הראשי

רון מילוא

פרופסור במחלקה למדעי הצמח במכון ויצמן למדע ויושב ראש הוועד המנהל של האקדמיה הצעירה הישראלי

רון מילוא (נולד ב-11 בפברואר 1975) הוא פרופסור במחלקה למדעי הצמח במכון ויצמן למדע ויושב ראש הוועד המנהל של האקדמיה הצעירה הישראלית.

פרסם עשרות מאמרים מדעיים ורשם חמישה פטנטים.

ביוגרפיהעריכה

רון מילוא נולד בחיפה. בוגר תיכון גלילי. בגיל 15 זכה באולימפיאדה הארצית לפיזיקה. הוא בעל תואר ראשון בהצטיינות במסגרת תוכנית תלפיות, תואר שני בהנדסת חשמל ותואר שלישי במעבדתו של פרופסור אורי אלון במכון ויצמן למדע. תחומי המחקר שלו הם: ביולוגיה מערכתית, מטבוליזם, ביולוגיה חישובית, אבולוציה, פוטוסינתזה וביולוגיה מולקולרית.

במעבדתו של מילוא במכון ויצמן למדע חוקרים את עקרונות הפעולה של רשתות אנרגיה ומטבוליזם, מתוך שאיפה לרתום את כלי המחקר של הביולוגיה המערכתית למען אתגרי הסביבה והקיימות. את יעילות הפוטוסינתזה חוקרים על ידי פירוקה לשלבים ומציאת צווארי הבקבוק והגורמים המגבילים בתהליך המרת פוטונים למולקולות של פחמימות על מנת להבין את האילוצים המעצבים את תכונות הפוטוסינתזה ואת המגבלות על יצרנותם המקסימלית של צמחים ויצורים פוטוסינתטיים אחרים. בנוסף, חוקרים את האפשרויות, הגבולות והאופטימאליות של חילוף החומרים של פחמן במטרה להבין את עקרונות העיצוב הבסיסיים שאליהם התכנסה האבולוציה וללמוד איך לשפר את היכולת לייצר מזון ודלק ביתר יעילות, לשמר מים ולהשתמש בחנקן. כמו כן, מפתחים במעבדה BioNumbers, בסיס נתונים של מספרים ביולוגים שימושיים לחוקרים ולציבור הרחב. מודלים של אופטימליות מסייעים לבחינת הרעיונות הנוגעים לשקלול התמורות והכוחות הדומיננטיים של האבולוציה.

בשנת 2016 נבחר לכהן כיושב ראש הוועד המנהל של האקדמיה הצעירה הישראלית.[1]

מילוא נשוי ואב לשלוש בנות, מתגורר בכפר סבא.

פרסים והוקרהעריכה

פרסומים מדעיים (באנגלית)עריכה

  1. Shen-Orr, Ss; Milo, R; Mangan, S; Alon, U (2002). Network Motifs in the Transcriptional Regulation Network of Escherichia Coli. Nature Genetics. 31:64-68.
  2. Milo, R; Shen-Orr, S; Itzkovitz, S; Kashtan, N; Chklovskii, D; Alon, U (2002). Network Motifs: Simple Building Blocks of Complex Networks. Science. 298:824-827.
  3. Itzkovitz, S; Milo, R; Kashtan, N; Ziv, G; Alon, U (2003). Subgraphs in Random Networks. Physical Review E. 68.
  4. . Yeger-Lotem, E; Sattath, S; Kashtan, N; Itzkovitz, S; Milo, R; Pinter, Ry; Alon, U; Margalit, H (2004). Network Motifs in Integrated Cellular Networks of Transcription-Regulation and Protein-Protein Interaction. Proceedings of the National Academy of Sciences of the United States of America. 101:5934-5939.
  5. Milo, R; Itzkovitz, S; Kashtan, N; Levitt, R; Shen-Orr, S; Ayzenshtat, I; Sheffer, M; Alon, U (2004). Superfamilies of Evolved and Designed Networks. Science. 303:1538-1542.
  6. Milo, R; Itzkovitz, S; Kashtan, N; Levitt, R; Alon, U (2004). Response to Comment on "Network Motifs: Simple Building Blocks of Complex Networks" and "Superfamilies of Evolved and Designed Networks". Science. 305.
  7. Kashtan, N; Itzkovitz, S; Milo, R; Alon, U (2004). Topological Generalizations of Network Motifs. Physical Review E. 70.
  8. Kashtan, N; Itzkovitz, S; Milo, R; Alon, U (2004). Efficient Sampling Algorithm For Estimating Subgraph Concentrations and Detecting Network Motifs. Bioinformatics. 20:1746-1758.
  9. Itzkovitz, S; Milo, R; Kashtan, N; Newman, Mej; Alon, U (2004). Reply to "Comment on 'Subgraphs in Random Networks' ". Physical Review E. 70.
  10. De Rosbo, Nk; Kaye, Jf; Eisenstein, M; Mendel, W; Hoeftberger, R; Lassmann, H; Milo, R; Ben-Nun, A (2004). The Myelin-Associated Oligodendrocytic Basic Protein Region Mobp15-36 Encompasses the Immunodominant Major Encephalitogenic Epitope(s) For Sjl/j Mice and Predicted Epitope(s) For Multiple Sclerosis-Associated Hla-Drb1*1501. Journal of Immunology. 173:1426-1435.
  11. Itzkovitz, S; Levitt, R; Kashtan, N; Milo, R; Itzkovitz, M; Alon, U (2005). Coarse-Graining and Self-Dissimilarity of Complex Networks. Physical Review E. 71.
  12. Sigal, A; Milo, R; Cohen, A; Geva-Zatorsky, N; Klein, Y; Liron, Y; Rosenfeld, N; Danon, T; Perzov, N; Alon, U (2006). Variability and Memory of Protein Levels in Human Cells. Nature. 444:643-646.
  13. Geva-Zatorsky, N; Rosenfeld, N; Itzkovitz, S; Milo, R; Sigal, A; Dekel, E; Yarnitzky, T; Liron, Y; Polak, P; Lahav, G; Alon, U (2006). Oscillations and Variability in the P53 System. Molecular Systems Biology. 2.
  14. Sigal, A; Milo, R; Cohen, A; Geva-Zatorsky, N; Klein, Y; Alaluf, I; Swerdlin, N; Perzov, N; Danon, T; Liron, Y; Raveh, T; Carpenter, Ae; Lahav, G; Alon, U (2006). Dynamic Proteomics in Individual Human Cells Uncovers Widespread Cell-Cycle Dependence of Nuclear Proteins. Nature Methods. 3:525-531.
  15. Itzkovitz, S; Milo, R; Kashtan, N; Levitt, R; Lahav, A; Alon, U (2006). Recurring Harmonic Walks and Network Motifs in Western Music. Advances in Complex Systems. 9:121-132.
  16. Sigal, A; Danon, T; Cohen, A; Milo, R; Geva-Zatorsky, N; Lustig, G; Liron, Y; Alon, U; Perzov, N (2007). Generation of a Fluorescently Labeled Endogenous Protein Library in Living Human Cells. Nature Protocols. 2:1515-1527.
  17. Milo, Ron; Hou, J. H.; Springer, M, Brenner, M. P.; Kirschner, M. W. (2007). The Relationship Between Evolutionary and Physiological Variation in Hemoglobin. PNAS. 104.
  18. Shinar, G; Milo, R; Martinez, Mr; Alon, U (2007). Input-Output Robustness in Simple Bacterial Signaling Systems. Proceedings of the National Academy of Sciences of the United States of America. 104:19931-19935.
  19. Spiegel, I; Adamsky, K; Eshed, Y; Milo, R; Sabanay, H; Sarig-Nadir, O; Horresh, I; Scherer, Ss; Rasband, Mn; Peles, E (2007). A Central Role For Necl4 ( Syncam4) in Schwann Cell- Axon Interaction and Myelination. Nature Neuroscience. 10:861-869.
  20. Zaidel-Bar, R; Milo, R; Kam, Z; Geiger, B (2007). A Paxillin Tyrosine Phosphorylation Switch Regulates the Assembly and Form of Cell-Matrix Adhesions. Journal of Cell Science. 120:137-148.
  21. Cohen, Aa; Geva-Zatorsky, N; Eden, E; Frenkel-Morgenstern, M; Issaeva, I; Sigal, A; Milo, R; Cohen-Saidon, C; Liron, Y; Kam, Z; Cohen, L; Danon, T; Perzov, N; Alon, U (2008). Dynamic Proteomics of Individual Cancer Cells in Response to a Drug. Science. 322:1511-1516.
  22. Phillips, R; Milo, R (2009). A Feeling For the Numbers in Biology. Proceedings of the National Academy of Sciences of the United States of America. 106:21465-21471.
  23. Cohen, Aa; Kalisky, T; Mayo, A; Geva-Zatorsky, N; Danon, T; Issaeva, I; Kopito, Rb; Perzov, N; Milo, R; Sigal, A; Alon, U (2009). Protein Dynamics in Individual Human Cells: Experiment and Theory. PLoS ONE. 4.
  24. Milo, R; Schuldiner, M (2009). Weizmann Young pi Forum: the Power of Peer Support. Molecular Cell. 36:913-915.
  25. Milo, R (2009). What Governs the Reaction Center Excitation Wavelength of Photosystems i and II? Photosynthesis Research. 101:59-67.
  26. Geva-Zatorsky, N; Cohen, Aa; Eden, E; Dekel, E; Frenkel-Morgenstern, M; Issaeva, I; Danon, T; Cohen, L; Perzov, N; Milo, R; Sigal, A; Alon, U (2010). Dynamics Proteomics of Individual Cancer Cells in Response to Drugs. Febs Journal. 277:281.
  27. Moran, U; Phillips, R; Milo, R (2010). Snapshot: Key Numbers in Biology. Cell. 141:1262.
  28. Noor, E; Eden, E; Milo, R; Alon, U (2010). Central Carbon Metabolism as a Minimal Biochemical Walk Between Precursors For Biomass and Energy. Molecular Cell. 39:809-820.
  29. Milo, R; Jorgensen, P; Moran, U; Weber, G; Springer, M (2010). Bionumbers-the Database of Key Numbers in Molecular and Cell Biology. Nucleic Acids Research. 38:D750-D753.
  30. Savir, Y; Noor, E; Milo, R; Tlusty, T (2010). Cross-Species Analysis Traces Adaptation of Rubisco Toward Optimality in a Low-Dimensional Landscape. Proceedings of the National Academy of Sciences of the United States of America. 107:3475-3480.
  31. Bar-Even, A; Noor, E; Lewis, Ne; Milo, R (2010). Design and Analysis of Synthetic Carbon Fixation Pathways. Proceedings of the National Academy of Sciences of the United States of America. 107:8889-8894.
  32. Hart, Y; Mayo, Ae; Milo, R; Alon, U (2011). Robust Control of Pep Formation Rate in the Carbon Fixation Pathway of c-4 Plants by a Bifunctional Enzyme. Bmc Systems Biology. 5.
  33. Bar-Even, A; Noor, E; Flamholz, A; Buescher, Jm; Milo, R (2011). Hydrophobicity and Charge Shape Cellular Metabolite Concentrations. Plos Computational Biology. 7.
  34. Alperovitch-Lavy, A; Sharon, I; Rohwer, F; Aro, Em; Glaser, F; Milo, R; Nelson, N; Beja, O (2011). Reconstructing a Puzzle: Existence of Cyanophages Containing Both Photosystem-i and Photosystem-II Gene Suites Inferred from Oceanic Metagenomic Datasets. Environmental Microbiology. 13:24-32.
  35. Bar-Even, A; Noor, E; Savir, Y; Liebermeister, W; Davidi, D; Tawfik, Ds; Milo, R (2011). The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters. Biochemistry. 50:4402-4410.
  36. Sigal, A; Kim, Jt; Balazs, Ab; Dekel, E; Mayo, A; Milo, R; Baltimore, D (2011). Cell-to-Cell Spread of Hiv Permits Ongoing Replication Despite Antiretroviral Therapy. Nature. 477:95-U100.
  37. Noor, E; Milo, R (2012). Efficiency in Evolutionary Trade-Offs. Science. 336:1114-1115.
  38. Noor, E; Lewis, Ne; Milo, R (2012). A Proof For Loop-Law Constraints in Stoichiometric Metabolic Networks. Bmc Systems Biology. 6.
  39. Bar-Even, A; Flamholz, A; Noor, E; Milo, R (2012). Thermodynamic Constraints Shape the Structure of Carbon Fixation Pathways. Biochimica et Biophysica Acta-Bioenergetics. 1817:1646-1659.
  40. Farkash-Amar, S; Eden, E; Cohen, A; Geva-Zatorsky, N; Cohen, L; Milo, R; Sigal, A; Danon, T; Alon, U (2012). Dynamic Proteomics of Human Protein Level and Localization Across the Cell Cycle. PLoS ONE. 7.
  41. Bar-Even, A; Flamholz, A; Noor, E; Milo, R (2012). Rethinking Glycolysis: on the Biochemical Logic of Metabolic Pathways. Nature Chemical Biology. 8:509-517.
  42. Milo, R; Last, Rl (2012). Achieving Diversity in the Face of Constraints: Lessons from Metabolism. Science. 336:1663-1667.
  43. Noor, E; Bar-Even, A; Flamholz, A; Lubling, Y; Davidi, D; Milo, R (2012). An Integrated Open Framework For Thermodynamics of Reactions That Combines Accuracy and Coverage. Bioinformatics. 28:2037-2044.
  44. Flamholz, A; Noor, E; Bar-Even, A; Milo, R (2012). Equilibrator-the Biochemical Thermodynamics Calculator. Nucleic Acids Research. 40:D770-D775.
  45. Adadi, R; Volkmer, B; Milo, R; Heinemann, M; Shlomi, T (2012). Prediction of Microbial Growth Rate Versus Biomass Yield by a Metabolic Network With Kinetic Parameters. Plos Computational Biology. 8.
  46. Bar-Even, A; Noor, E; Milo, R (2012). A Survey of Carbon Fixation Pathways Through a Quantitative Lens. Journal of Experimental Botany. 63:2325-2342.
  47. Bar-Even, A; Noor, E; Flamholz, A; Milo, R (2013). Design and Analysis of Metabolic Pathways Supporting Formatotrophic Growth For Electricity-Dependent Cultivation of Microbes. Biochimica et Biophysica Acta-Bioenergetics. 1827:1039-1047.
  48. Noor, E; Haraldsdottir, Hs; Milo, R; Fleming, Rmt (2013). Consistent Estimation of Gibbs Energy Using Component Contributions. Plos Computational Biology. 9.
  49. Keren, L; Zackay, O; Lotan-Pompan, M; Barenholz, U; Dekel, E; Sasson, V; Aidelberg, G; Bren, A; Zeevi, D; Weinberger, A; Alon, U; Milo, R; Segal, E (2013). Promoters Maintain Their Relative Activity Levels Under Different Growth Conditions. Molecular Systems Biology. 9.
  50. Milo, R (2013). What is the Total Number of Protein Molecules Per Cell Volume? a Call to Rethink Some Published Values. Bioessays. 35:1050-1055.
  51. Zelcbuch, L; Antonovsky, N; Bar-Even, A; Levin-Karp, A; Barenholz, U; Dayagi, M; Liebermeister, W; Flamholz, A; Noor, E; Amram, S; Brandis, A; Bareia, T; Yofe, I; Jubran, H; Milo, R (2013). Spanning High-Dimensional Expression Space Using Ribosome-Binding Site Combinatorics. Nucleic Acids Research. 41.
  52. Noor, E; Flamholz, A; Liebermeister, W; Bar-Even, A; Milo, R (2013). A Note on the Kinetics of Enzyme Action: a Decomposition That Highlights Thermodynamic Effects. Febs Letters. 587:2772-2777.
  53. Levin-Karp, A; Barenholz, U; Bareia, T; Dayagi, M; Zelcbuch, L; Antonovsky, N; Noor, E; Milo, R (2013). Quantifying Translational Coupling in E. Coli Synthetic Operons Using Rbs Modulation and Fluorescent Reporters. Acs Synthetic Biology. 2:327-336.
  54. Tepper, N; Noor, E; Amador-Noguez, D; Haraldsdottir, Hs; Milo, R; Rabinowitz, J; Liebermeister, W; Shlomi, T (2013). Steady-State Metabolite Concentrations Reflect a Balance Between Maximizing Enzyme Efficiency and Minimizing Total Metabolite Load. PLoS ONE. 8.
  55. Flamholz, A; Noor, E; Bar-Even, A; Liebermeister, W; Milo, R (2013). Glycolytic Strategy as a Tradeoff Between Energy Yield and Protein Cost. Proceedings of the National Academy of Sciences of the United States of America. 110:10039-10044.
  56. Shepon, A; Israeli, T; Eshel, G; Milo, R (2013). Ecotime-an Intuitive Quantitative Sustainability Indicator Utilizing a Time Metric. Ecological Indicators. 24:240-245.
  57. Noor, E; Bar-Even, A; Flamholz, A; Reznik, E; Liebermeister, W; Milo, R (2014). Pathway Thermodynamics Highlights Kinetic Obstacles in Central Metabolism. Plos Computational Biology. 10.
  58. Flamholz, A; Phillips, R; Milo, R (2014). The Quantified Cell. Molecular Biology of the Cell. 25:3497-3500.
  59. Eshel, G; Shepon, A; Makov, T; Milo, R (2014). Reply to Metson et al.: the Importance of Phosphorus Perturbations. Proceedings of the National Academy of Sciences of the United States of America. 111:E4908.
  60. Liebermeister, W; Noor, E; Flamholz, A; Davidi, D; Bernhardt, J; Milo, R (2014). Visual Account of Protein Investment in Cellular Functions. Proceedings of the National Academy of Sciences of the United States of America. 111:8488-8493.
  61. Eshel, G; Shepon, A; Makov, T; Milo, R (2014). Land, Irrigation Water, Greenhouse Gas, and Reactive Nitrogen Burdens of Meat, Eggs, and Dairy Production in the United States. Proceedings of the National Academy of Sciences of the United States of America. 111:11996-12001.
  62. Farkash-Amar, S; Zimmer, A; Eden, E; Cohen, A; Geva-Zatorsky, N; Cohen, L; Milo, R; Sigal, A; Danon, T; Alon, U (2014). Noise Genetics: Inferring Protein Function by Correlating Phenotype With Protein Levels and Localization in Individual Human Cells. Plos Genetics. 10.
  63. Kaushansky, N; Eisenstein, M; Boura-Halfon, S; Hansen, Be; Nielsen, Ch; Milo, R; Zeilig, G; Lassmann, H; Altmann, Dm; Ben-Nun, A (2015). Role of a Novel Human Leukocyte Antigen-Dqa1*01:02; Drb1*15:01 Mixed Isotype Heterodimer in the Pathogenesis of "Humanized" Multiple Sclerosis-Like Disease. Journal of Biological Chemistry. 290:15260-15278.
  64. Bar-Even, Arren; Milo, Ron; Noor, Elad; Tawfik, Dan S. (2015). The Moderately Efficient Enzyme: Futile Encounters and Enzyme Floppiness. Biochemistry. 54.
  65. Keren, L; Van Dijk, D; Weingarten-Gabbay, S; Davidi, D; Jona, G; Weinberger, A; Milo, R; Segal, E (2015). Noise in Gene Expression is Coupled to Growth Rate. Genome Research. 25:1893-902.
  66. Eshel, G; Shepon, A; Makov, T; Milo, R (2015). Reply to Tichenor: Proposed Update to Beef Greenhouse Gas Footprint is Numerically Questionable and Well Within Current Uncertainty Bounds. Proceedings of the National Academy of Sciences of the United States of America. 112:E822-E823.
  67. Eshel, G; Shepon, A; Makov, T; Milo, R (2015). Partitioning United States' Feed Consumption Among Livestock Categories For Improved Environmental Cost Assessments. Journal of Agricultural Science. 153:432-445.
  68. Zelcbuch, L; Razo-Mejia, M; Herz, E; Yahav, S; Antonovsky, N; Kroytoro, H; Milo, R; Bar-Even, A (2015). An in Vivo Metabolic Approach For Deciphering the Product Specificity of Glycerate Kinase Proves That Both E. Coli's Glycerate Kinases Generate 2-Phosphoglycerate. PLoS ONE. 10.
  69. Davidi, D; Noor, E; Liebermeister, W; Bar-Even, A; Flamholz, A; Tummler, K; Barenholz, U; Goldenfeld, M; Shlomi, T;Milo, R (2016). Global Characterization of in Vivo Enzyme Catalytic Rates and Their Correspondence to in Vitro Kcat Measurements. PNAS. 113.
  70. Barenholz, U; Keren, L; Segal, E; Milo, R (2016). A Minimalistic Resource Allocation Model to Explain Ubiquitous Increase in Protein Expression With Growth Rate. PLoS ONE. 11.
  71. Shamir, M; Bar-On, Y; Phillips, R; Milo, R (2016). Snapshot: Timescales in Cell Biology. Cell. 164.
  72. Sender, Ron; Fuchs, Shai; Milo, Ron (2016). Are we Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans. Cell. 164:337-340.

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